Transparency
Market Research Reports incorporated a definite business overview and
investigation inclines on “Prokaryotic
Expression Systems Market”.
This report likewise incorporates more illumination about fundamental
review of the business including definitions, requisitions and
worldwide business sector industry structure. Expression systems are
used for the production of large number of biological products such
as proteins, enzymes, amino acids, biopolymers from recombinant DNA
molecules. The process involves introduction of a foreign DNA into
the host cell. The first step involved in various biomolecule
production using expression systems is identifying and isolating the
DNA to be introduced into the host. This is followed by vector
identification and construction of recombinant vector. An expression
vector or plasmid which is responsible for protein expression in cell
possess various components such as promoter, translation initiation
sequence, start codon, termination codon and transcription
termination sequence. Among the two general expression systems such
as prokaryotic and eukaryotic systems, prokaryotic expression systems
produce large quantities of protein quickly and economically using
bacterial host organisms such Escherichia coli, Pseudomonas.
alcaligenes, Corynebacterium glutamicum, and Bacillus subtilis.
Advances in genetic engineering, ability to clone and express a gene
in the heterologus host have made possible the capability to produce
any protein as a diagnostics and therapeutic agent. A large number of
expression vectors are available commercially or in research
laboratories, though only limited numbers of vectors are suitable for
industrial use. Certain factors affecting prokaryotic expression
system include codon bias, protein folding, protein phosphorylation
and glycosylation and promoter strength.
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The
global prokaryotic expression systems market has been segmented into
host types, end users, products, applications and geography. Host
types have been further segmented into E. coli systems, C.
glutamicum, P. alcaligenes, B. subtilis and archaea. End users for
prokaryotic expression systems include contract research
organizations, academic research, pharmaceutical and biotechnology
companies and others. Applications for the prokaryotic expression
systems include industrial proteins, research and therapeutic
proteins. Products obtained from prokaryotic expression systems
include enzymes, antibiotics, amino acids, pigments, biopolymers,
lipases and ascorbic acid. Geographically, the prokaryotic expression
systems market can be categorized into four major regions namely
North America, Europe, Asia-Pacific and Rest of the World. Growth in
biologics and proteomics and the associated increase in research
activities are expected to drive the growth of the global prokaryotic
expression systems market. Emerging economies of Asia Pacific, Latin
America, and the Middle East countries present significant
opportunities for the growth of this market.
E.
coli is one of the most popular hosts for artificial gene expression.
Production of proteins with the help of E. coli is the simplest,
cheapest and quickest method. There is a vast amount of knowledge
about the genetics, genomic sequence and physiology of E. coli
greatly facilitating gene cloning and production thus making it a
popular and most widely employed host. Furthermore, ability to
express heterologus proteins in a huge quantity i.e. higher
volumetric productivity along with high growth rates also makes E.
coli the most suitable host. Corynebacterium is a non pathogenic gram
positive bacteria are used for commercial production of amino acids
such as glutamate and lysine as well as components of animal feed and
pharmaceutical products. C. glutamicum species has been used for
expression of functionally active human epidermal growth factor. P.
fluorescens is used for development of vaccines and bio therapeutics.
However
certain limitations with the use of prokaryotic expression systems
include inappropriate mechanism of post translational modifications.
Also, E coli possess toxic cell wall pyrogens and thus require
extensive testing before use of products. Moreover, prokaryotic
proteins synthesized in bacteria sometimes are unstable or lack
biological activity. Stabilization and formulation of proteins for
their use in industrial and therapeutic applications with the help of
biological catalysts is further expected to pose a challenge to the
success of prokaryotic expression systems.
Some
of the key players contributing to the global prokaryotic expression
systems market include Agilent Technologies, Inc., Bio-Rad
Technologies, Inc., Merck Millipore, Promega Corporation, Qiagen,
Sigma Aldrich Corporation and Thermo Fischer Scientific, Inc. amongst
various others.
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This
research report analyzes this market depending on its market
segments, major geographies, and current market trends. Geographies
analyzed under this research report include
- North America
- Asia Pacific
- Europe
- Rest of the World
This
report provides comprehensive analysis of
- Market growth drivers
- Factors limiting market growth
- Current market trends
- Market structure
- Market projections for upcoming years
This
report is a complete study of current trends in the market, industry
growth drivers, and restraints. It provides market projections for
the coming years. It includes analysis of recent developments in
technology, Porter’s five force model analysis and detailed
profiles of top industry players. The report also includes a review
of micro and macro factors essential for the existing market players
and new entrants along with detailed value chain analysis.
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